WHAT IS THE PATHOGENESIS OF cGVHD?

Chronic graft-versus-host disease is a complex multisystem disorder caused by an immune imbalance following an allogeneic HCT, which leads to serious and potentially life-threatening complications from both inflammatory and fibrotic processes. cGVHD is mediated by multiple immune pathways and is characterized by¹

Although the understanding of the pathophysiology of cGVHD is improving, there is still much to be uncovered about the nature of the inflammatory cascade and the complex dynamics of the inflammatory and fibrotic processes.

Chronic graft-versus-host disease presents multiple challenges for both clinicians and patients, specifically through manifestations of inflammation and fibrosis.

Although advances have been made in the understanding of cGVHD, many questions still remain.

cGVHD,chronicgraft-versus-hostdisease.

Although the understanding of the pathophysiology of cGVHD is improving, there is still much to be uncovered about the nature of the inflammatory cascade and the complex dynamics of the inflammatory and fibrotic processes.

BTK, Bruton’s tyrosine kinase; cGVHD, chronic graft-versus-host disease; HCT, hematopoietic cell transplant; IL-2, interleukin 2; JAK, Janus-associated kinase; ROCK, rho-associated coiled-coil–containing protein kinase.