EoE Pathophysiology
*IL-4 induces naive Th0 cells to differentiate into Th2 cells, which secrete IL-4, IL-5, and IL-13 in EoE5 ; ILC2 cells are increased in EoE and also secrete IL-5 and IL-137 ; † IL-4 and IL-13 induce B-cell isotype switching to produce IgE, activating mast cells and basophils, resulting in degranulation,4,19 while IL-4 can also directly activate mast cells15,16; ‡ Not approved for EoE; § Topical swallowed steroids include swallowed puffs from inhalers, suspension, viscous slurry, and effervescent tablets.3
IL=interleukin; ILC2=type 2 innate lymphoid cell; Th0=naive T helper; Th2=Type 2 helper.
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