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Several cytokines, including IL-4, IL-13, and IL-31, contribute to type 2 inflammation and the clinical disease features of atopic dermatitis, including barrier dysfunction, increased susceptibility to skin infection and chronic itch which all drive eczematous skin lesions.3–7*
Atopic dermatitis is a chronic, inflammatory skin disease in which the Th2 cytokines IL-4 and IL-13 are key drivers involved with the underlying inflammatory process.1