Loss of Smell Is a Key Symptom in CRSwNP
Chronic rhinosinusitis with nasal polyps (CRSwNP):
A chronic type 2 inflammatory disease of the nasal/paranasal sinuses of the upper airway
characterized by rhinosinusitis and bilateral nasal polyps1,2
Type 2 inflammation drives disease pathology in up to 87% of patients with CRSwNP4
Loss of smell may be used as a diagnostic symptom and may predict CRSwNP patients with poor long-term outcomes requiring approaches beyond the standard of care
Loss of Smell: A Diagnostic Symptom
Steroid and Surgical Effects on Loss of Smell
Type 2 inflammation in CRSwNP is associated with loss of smell
*Clinical consequences are listed in descending order based on patient questionnaire: “Please mark the most important items affecting your health.” †Loss of smell is included in CRSwNP diagnostic criteria
in the following international guideline publications: EPOS 2020, ICAR:RS 2021, EUFOREA 2021, and EAACI 2021.
CRSwNP, chronic rhinosinusitis with nasal polyps; EAACI, European Academy of Allergy and Clinical Immunology; EPOS, European Position Paper on Rhinosinusitis and Nasal Polyps; EUFOREA, European
Forum for Research and Education in Allergy and Airway Diseases; ICAR:RS, International Consensus Statement on Allergy and Rhinology: Rhinosinusitis; IL, interleukin; SCS, systemic corticosteroids;
SOC, standard of care.
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