Prurigo Nodularis
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Mechanism of Prurigo Nodularis Disease
In this comprehensive exploration, we delve into the intricate pathophysiology of Prurigo Nodularis (PN), highlighting the pivotal roles of neuronal sensitization, inflammation, and pruritus. This challenging dermatological condition is characterized by dermatological condition histopathologic alterations, including enhanced hypervascularization, epidermal hyperkeratosis, and dermal fibrosis. Explore the connection between PN and the proinflammatory Th2 cytokine IL-13, shedding light on its binding to IL-4R across various skin components.
Prurigo Nodularis is a distinct, Chronic, Neural and Immune- Mediated skin disease characterized by intense itch and Nodular Lesions¹
Type 2 Inflammation may play a role in Prurigo Nodularis Pathophysiology1
Exact pathophysiology of PN is currently not understood. Based on the evolving literature, type 2 inflammation may play a role in PN.