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Rezurock Economic Value

Rezurock is a cost-effective treatment when compared to the available treatments against 3L cGVHD,with a coverage resulting in a neutral/limited incremental budget impact.1

Cost-effectiveness Analysis2,4

  • At a WTP of £30,000 per QALY gained, Belumosudil demonstrated a significant clinical benefit versus BATs with an incremental gain of: 0.854 QALYs
  • Belumosudil is cost-effective vs. BAT in patients aged 12 years and older with cGVHD who received at least two prior lines of systemic therapy.

Budget-impact Analysis3

  • Costs savings associated with the management of AEs (e.g., neutropenia and thrombocytopenia) in 2026 are projected to be ≈$108.4M
  • Costs savings associated with healthcare resources utilization (e.g., emergency room visits, ICU stays) in 2026 are projected to be ≈$65.1M

Belumosudil allows for the offset of healthcare system costs compared with BAT, resulting in a $128.8M cost savings from a national US payer perspective

Abbreviations

3L: Third line; WTP: Willingness-to-pay; AE: Adverse event; RWE: Real-world evidence; ICU: Intensive Care Unit; LOT: Line of therapy; BAT: Best available therapies; cGVHD: Chronic graft-versus-host disease; US: United States.

  1. Carlos R. Bachier, Jeffrey R. Skaar, Sumudu Dehipawala, Benjamin Miao, Jonathan Ieyoub & Haya Taitel (2022) budget impact analysis of belumosudilfor chronic graft-versus-host disease treatment in the United States, Journal of Medical Economics, DOI: 10.1080/13696998.2022.2087408
  2. Data on file. Data on Sanofi file, mini-CVD, Final Draft_without naïve comparison section_clean.
  3. Carlos R. Bachier, Jeffrey R. Skaar, Sumudu Dehipawala, Benjamin Miao, Jonathan Ieyoub & Haya Taitel (2022) budget impact analysis of belumosudil for chronic graft-versus-host disease treatment in the United States, Journal of Medical Economics, DOI: 10.1080/13696998.2022.2087408
  4. NICE Guidance: ‘Belumosudil for treating chronic graft-versus-host disease after 2 or more systemic treatments in people 12 years and over’. Available at: https://www.nice.org.uk/guidance/ta949
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