You can imagine more than 90% of CRSwNP Patients losses their ability's of smell

Smell is mediated by Olfactory Sensory Neurons in the olfactory epithelium. Horizontal Basal Stem Cells regenerate these Olfactory Sensory Neurons, maintaining the sense of smell.

    1. Yan X, Whitecroft LK, Hummel T. Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.Laryngoscope Investig Otolaryngol. 2020;28;5(6):992-1002. doi:10.1002/lio2.485
    2. Chen M, Reed RR, Lane AP. Chronic inflammation directs an olfactory stem cell functional switch from neuroregeneration to immune defense. Cell Stem Cell. 2019;25(4):501-513.doi:10.1016/j.stem.2019.08.011
    3. Rouyar A, Classe M, Gorski R, et al. Type 2/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model. Allergy. 2019;74(3):549-559. doi:10.1111/all.13559
    4. Mullol J, Mariño-Sánchez F, Valls M, et al. The sense of smell in chronic rhinosinusitis. J Allergy Clin Immunol. 2020;145(3):773-776. doi:10.1016/j.jaci.2020.01.024
    5. DUPIXENT Summary of Product Characteristics, 2023