DEVELOPMENT OF INSULIN FORMULATIONS AND ROUTES OF DELIVERY WITH MORE FAVORABLE PK CHARACTERISTICS
STRATEGIES ADVANTAGES LIMITATIONS
Intranasal insulin Significantly faster onset and offset in action with potential to reduce residual insulin activity associated with pre-exercise meal bolus

  • Not widely available

  • Long-term safety is not clear
Continuous intraperitoneal insulin infusion

  • Faster onset and offset action

  • Improves HbA1c with less hypoglycemia

  • Invasive procedures

  • Carries risk of infection and immunogenicity
Intravenous (IV) CL insulin delivery models

  • Rapid delivery with no delay in absorption

  • Would bypass limitations of SC route

  • Invasive

  • Prone to complications such as infections, thrombosis

  • Less feasible for ambulatory use

MAT-BH-2200900/V1/Nov 2022