Emerging role of gut microbiota in functional gastrointestinal disorders

Current evidence sheds light on the influential role of intestinal dysbiosis in patients with FGIDs. There remains FMT’s use as a therapeutic option in patients with FGID, especially those with IBS, has not yielded favorable results due to differences in dosing, route, and duration of therapy utilized across studies. In the future, understanding and identifying specific groups of patients with FGID in whom intestinal dysbiosis plays a central role in the pathogenesis of the disease, independent of other factors, who would benefit from gut microbial modulation, through large population-based observational and randomized controlled interventions needs effectuation. Wide variations in observed changes in the species and genera of these patients dependent on the region (Asian versus European), methodology (16 sRNA sequencing versus shotgun sequencing), and sites (fecal versus mucosal; duodenum versus colon) studied.

Bidirectional interaction exists between functional/mucosal gut physiology

Bidirectional gut microbial (bacterial) interactions due to intestinal dysbiosis have strong connection with symptoms in functional dyspepsia and IBS#.

^FGIDs - functional gastrointestinal disorders   # IBS - Irritable Bowel Syndrome

    1. Augustine P, Ghoshal U, Zulfikar R, et al. Emerging Role of Gut Microbiota in Functional Gastrointestinal Disorders [Internet].
    Available at: https://link.springer.com/chapter/10.1007/978-981-16-7672-7_3. Accessed on 16 Sept 2022

MAT-IN-2201306 V1.0 06/22