Individualizing r-ATG exposure: Key to overcome drawbacks of current weight-based r-ATG dosing

Pharmacokinetic modeling studies and clinical trials demonstrate a strong relationship between the r-ATG exposure and T-cell reconstitution. This presentation explains about:

Current r-ATG dosing strategy and guidelines
Association between r-ATG exposure and CD4+ immune reconstitution
Association between r-ATG exposure and the 5-year overall survival outcome
PARACHUTE study
Retrospective review of use of individualized dosing of r-ATG
Body weight and ALC-based r-ATG nomogram dosing in patients with inborn errors of metabolism
Optimal active r-ATG exposure associated with minimum risk of virus reactivation
Individualization of r-ATG dosing and the way forward