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Effect of micellised and fat-soluble vitamin D3 supplementation in Indian children

Studies suggest that about 50% dose of vitamin D is absorbed in the intestine henceforth attaining serum 25(OH)D concentrations of ~20ng/mL in children is challenging. In this study, the effect of FS and MW vitamin D supplements were studied in pre- and post- fat solubility and water miscibility in children and it was observed that when compared to fat-soluble formulation, the rise in serum 25(OH)D concentrations was greatest with the water-miscible formulation (31.8 vs. 23.7 ng/ml), although serum ALP levels decreased in both groups. However, a significant decline was observed in the water miscible group. 

The finding also discussed the impact on hyperparathyroidism and calcium in the study group. It was established that maximum absorption is facilitated by molecules with micellization. A monthly dose of water-soluble vitamin D3 (60,000 IU) was more efficient at raising serum 25(OH)D levels.

Effects of Micellized & Fat-soluble Vitamin D3 Supplementation in Children

25(OH)D - 25-hydroxyvitamin D; PTH - parathyroid hormone; FS – fat soluble; WM – water miscible; ALP – alkaline phosphatase


  1. Marwaha R, Yenamandra V, Ganie M, Sethuraman G, Sreenivas V, Ramakrishnan L, et al. Efficacy of micellized vs. fat-soluble vitamin D3 supple mentation in healthy school children from Northern India. J Pediatr Endocrinol Metab. 2016 Dec 1;29(12):1373–1377.

Study details

Marwaha 2016 - Open-labeled non- randomized pilot study recruited 156 healthy children, aged 13–14 years from January through July 2015 in two schools located in New Delhi. The children received either fat soluble or water soluble vitamin D supplements for 6 months.

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MAT-IN-2301310 V1.0 06/23