Science at Sanofi

This educational video examines the prevalence of moderate and severe atopic dermatitis in children, presenting data that describes the significant disease burden and its impact on both pediatric patients and their families. The content explores current challenges in achieving optimal disease control in children with moderate and severe atopic dermatitis, providing healthcare professionals with evidence-based insights into the clinical management complexities of this patient population.

This educational video focuses on the role of type 2 inflammation in atopic dermatitis (AD) and prurigo nodularis (PN), examining how this inflammatory process contributes to cutaneous manifestations in both conditions.

Dr. Elmariah discusses atopic dermatitis and prurigo nodularis as distinct diseases that can coexist in some patients. The presentation addresses the diagnostic considerations and explores the multidimensional burden of both conditions on patients' quality of life.

Podcast Dr. Dana Hajan

Discover the science beyond histamine: This video reveals how chronic itch in atopic dermatitis is predominantly mediated through non-histaminergic pathways. Learn how IL-4 and IL-13, key drivers of type 2 inflammation, create a critical intersection between inflammatory cascades and neural itch signaling. Understand the clinical implications of targeting these dual cytokines to simultaneously address both inflammation and the persistent itch cycle that significantly impacts patient quality of life.

This video provides insights into the key components and functions of the epithelial barriers in the skin. It highlights how barrier dysfunction plays a central role in the pathology of atopic dermatitis and emphasizes the importance of transepidermal water loss as a marker of barrier integrity and disease severity.

This video explores the long-term, multi-dimensional burden of moderate-to-severe atopic dermatitis, highlighting its impact beyond the skin. It emphasizes the importance of early intervention targeting type 2 inflammation to alter the disease course and prevent long-term comorbidities.

This video highlights that the burden of atopic dermatitis in adults extends beyond skin symptoms, encompassing a broad spectrum of atopic and non-atopic comorbidities. These related conditions have a major impact on patient care, clinical decisions, and overall quality of life.

This video highlights prurigo nodularis (PN) as a systemic disorder driven by neural inflammation and immune dysregulation. Key inflammatory mediators IL-4 and IL-13, along with fibrosis, emerge as central features, emphasizing the need for targeted therapies that address both neural and immune pathways.