Complex immune dysregulation impact on QoL

Complex immune dysregulation contributes to significant clinical and QoL burdens of which:

	Accelerated PLT destruction in ITP and hemolysis in wAIHA lead to thrombocytopenia and increased bleeding risk in ITP and anemia in wAIHA^1,2

	Across, ITP, wAIHA, and SCD, immune dysregulation and inflammation may influence fatigue²⁻⁴

	In SCD, chronic inflammation and a hyperactive innate immune system help sustain the vicious cycle of VOCs⁶

	Thrombo-inflammation—marked by endothelial dysfunction, complement/coagulation dysregulation, and platelet/leukocyte activation—is increasingly recognized in ITP, wAIHA, and SCD^1,5,6

	Pain has a major impact on the QoL of individuals with SCD. Both acute and chronic pain have an inflammatory component, and can lead to eventual sensitization^4,7

ITP, immune thrombocytopenia; PLT, platelet; QoL, quality of life; SCD, sickle cell disease; wAIHA, warm autoimmune hemolytic anemia; VOC, vaso-occlusive crisis.

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Loriamini M, et al. Int J Mol Sci. 2024;25(8):4296.
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Osunkwo I, et al. Am J Hematol. 2021;96(4):404-417.
Conran N, De Paula EV. Haematologica. 2020;105(10):2380-2390.
Capecchi M, et al. J Clin Med. 2021;10(8):1764.
Gupta K, et al. Am J Physiol Regul Integr Comp Physiol. 2018;315(1):R104-R112.