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IL4 and IL13 important role in Chronic Itch

IL4 and IL13 important role in Chronic Itch

Discover the science beyond histamine: This video reveals how chronic itch in atopic dermatitis is predominantly mediated through non-histaminergic pathways. Learn how IL-4 and IL-13, key drivers of type 2 inflammation, create a critical intersection between inflammatory cascades and neural itch signaling. Understand the clinical implications of targeting these dual cytokines to simultaneously address both inflammation and the persistent itch cycle that significantly impacts patient quality of life.

Practical Approach in Understanding PN Pathophysiology

Practical Approach in Understanding PN Pathophysiology

This video highlights prurigo nodularis (PN) as a systemic disorder driven by neural inflammation and immune dysregulation. Key inflammatory mediators IL-4 and IL-13, along with fibrosis, emerge as central features, emphasizing the need for targeted therapies that address both neural and immune pathways. 

Clinical Indicators of COPD: A GOLD Guidelines Review

Clinical Indicators of COPD: A GOLD Guidelines Review

This video highlights the key insights from the 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report, presenting a clear, structured, and evidence-based approach to the diagnosis, assessment, and management of COPD.

Adaptive Eating Behaviors in EoE

Adaptive Eating Behaviors in EoE

Pediatric EoE: Indicators for Early Diagnosis and Intervention

Pediatric EoE: Indicators for Early Diagnosis and Intervention

Nirsevimab RWD Metanalysis

Nirsevimab RWD Metanalysis

Safety and efficacy of Avalglucosidase Alfa versus Alglucosidase Alfa in patints with Late-Onset Pompe Disease (COMET): a phase 3, randomized, multicentral study results

Safety and efficacy of Avalglucosidase Alfa versus Alglucosidase Alfa in patints with Late-Onset Pompe Disease (COMET): a phase 3, randomized, multicentral study results

Long-term Safety and Efficacy of Avalglucosidase Alfa IN Patients with Late-Onset Pompe Disease (NEO-EXT)

Long-term Safety and Efficacy of Avalglucosidase Alfa IN Patients with Late-Onset Pompe Disease (NEO-EXT)

Patient morbidity and mortality in BP

Patient morbidity and mortality in BP

Many factors, including older age and multimorbidity, are associated with mortality in bullous pemphigoid. Read this article to find out more

What is Bullous Pemphigoid

What is Bullous Pemphigoid

The heterogeneous presentation of bullous pemphigoid may shed light on why patients are underdiagnosed. Read the article to learn more

Considerations for bullous pemphigoid management

Considerations for bullous pemphigoid management

The management of bullous pemphigoid is challenging and new treatment approaches are needed. Read this article to find out more.

Pathophysiology of Bullous Pemphigoid

Pathophysiology of Bullous Pemphigoid

In bullous pemphigoid, autoimmunity to BP180 and BP230 is thought to trigger a type 2 inflammatory response. Read this article to find out more