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Campus
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Campus
  • Science

Atherothrombosis

Post-hoc analysis of the HOST-EXAM extended study assessing the effect of age on antiplatelet monotherapy during chronic maintenance post-PCI

Post-hoc analysis of the HOST-EXAM extended study assessing the effect of age on antiplatelet monotherapy during chronic maintenance post-PCI

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Ticagrelor versus clopidogrel in myocardial infarction patients with high bleeding riskrisk: A report from the SWEDEHEART registry

Ticagrelor versus clopidogrel in myocardial infarction patients with high bleeding riskrisk: A report from the SWEDEHEART registry

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De-escalation strategies in anti-platelet therapy: Understanding when to switch from a potent agent

De-escalation strategies in anti-platelet therapy: Understanding when to switch from a potent agent

De-escalation reduces bleeding risks in ACS. There are different strategies that can be described as de-escalation including guided and unguided. What is the current evidence regarding the different de-escalation strategies? And which patients are candidates for de-escalation strategies? VDO from expert (Prof.Sibbing)

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Findings from extended study in patients with CAD

Findings from extended study in patients with CAD

HOST-EXAM Extended study: Clopidogrel monotherapy had lower discontinuation rate (8% vs. 13.5%), reduced risk of death, MI, stroke, ACS readmission, and bleeding. Long-term clopidogrel use preferred for CAD secondary prevention.

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Long-term clopidogrel monotherapy vs prolonged DAPT beyond 12 months after PCI in high-risk patients

Long-term clopidogrel monotherapy vs prolonged DAPT beyond 12 months after PCI in high-risk patients

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Ticagrelor vs clopidogrel use in high bleeding risk in hospitalized patients with acute coronary syndrome: findings from the CCC–ACS project

Ticagrelor vs clopidogrel use in high bleeding risk in hospitalized patients with acute coronary syndrome: findings from the CCC–ACS project

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Meta-analysis of 8 studies (N=29,217) on DAPT in elderly CAD patients published 2007-2020.

Meta-analysis of 8 studies (N=29,217) on DAPT in elderly CAD patients published 2007-2020.

Limited comparison of baseline characteristics due to lack of age stratification in many studies. Higher risk of bleeding events with prasugrel/ticagrelor vs clopidogrel. No difference in efficacy endpoint rates. Results unchanged after excluding non-RCTs, high statistical heterogeneity in endpoint analysis.

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