BTK Enzyme

The Bruton’s Tyrosine Kinase (BTK) enzyme is a promising new focus of research^1,2

BTK is vital for activation of both B cells and microglia in MS.^1,2

In B cells, BTK promotes proliferation, antibody production, and cytokine secretion^1,2
When activated, BTK can shift microglia from their homeostatic to their disease-associated state^1,2
BTK is highly expressed in microglia within lesion tissue in patients with SPMS^1,2

Modulation of BTK may down regulate inflammation ^2,4

For more information about Acute and Smoldering Inflammation, click on this link:

BTK=Bruton's Tyrosine Kinase; IL=interleukin; MS=multiple sclerosis; NF-kb=Nuclear factor kappa B; SPMS=secondary progressive multiple sclerosis;TNF=tumor necrosis factor.

Frisch ES, Pretzsch R, Weber MS. A milestone in multiple sclerosis therapy: monoclonal antibodies against CD20_yet progress continues. Neurotherapeutics. 2021;18(3):1602-1622.
Keaney J, Gasser J, Gillet G, Scholz D, Kadiu I. Inhibition of Bruton's tyrosine kinase modulates microglial phagocytosis: therapeutic implications for Alzheimer's disease. J Neuroimmune Pharmacol. 2019;14(3):448-461.
Häusser-Kinzel S, Weber MS. The role of B cells and antibodies in multiple sclerosis, neuromyelitis optica, and related disorders. Front Immunol. 2019;10:201. doi:10.3389/fimmu.2019.00201
Hendriks RW. Drug discovery: new BTK inhibitor holds promise. Nat Chem Biol. 2011;7(1):4-5.

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The Bruton’s Tyrosine Kinase (BTK) enzyme is a promising new focus of research1,2

Modulation of BTK may down regulate inflammation 2,4

Abbreviations

References

The Bruton’s Tyrosine Kinase (BTK) enzyme is a promising new focus of research^1,2

Modulation of BTK may down regulate inflammation ^2,4