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Renal involvement in Fabry disease

Think Fabry, think renal involvement that may present early in life and could go undetected.

Renal_Manifestations_Graph

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Adapted from Schiffmann R et al, 2009; Ortiz A et al, 2008; Germain DP, 2010; Ramaswami U et al, 2010; Eng CM et al, 2006; Tøndel C et al, 2013; and Banikazemi M et al, 2007.1,2,4,6-9
*Accumulation of GL-3 starts in utero.3
ESRD, end-stage renal disease; GL-3, globotriaosylceramide.

  • Early and progressive GL-3 accumulation can lead to irreversible organ damage and potentially life-threatening clinical events2
  • Renal damage may occur with podocyte injury, starting as early as the first decade of life, despite minimal or normal microalbuminuria3,4
  • Renal biopsy can provide direct assessment of the level of pathological structural changes and may help guide the decision of when to initiate treatment11

Fabry disease patients with renal involvement can progress to ESRD within 4 years*,10,11

Screen for Fabry disease if you see unexplained CKD**,12

Screen those with unexplained CKD aged:12

<50 years old, male

male

Any age, female

female
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Especially if they have:12,13

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Hypohidrosis

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Angiokeratoma

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Acroparesthesia

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Family history

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Heat/cold intolerance

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LVH

Safety

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MAT-BE-2500570 (ver. 1) 05/2025