Skip To Main Content
Deze website is alleen bedoeld voor zorgverleners van België en Luxemburg.
Campus
  • Wetenschap
  • Hulpmiddelen
Campus
  • Wetenschap
  • Hulpmiddelen
View Full Results

Chronic Rhinosinusitis with Nasal Polyps: The Interplay of Type 2 Inflammation and Smell Loss

Author : Sanofi
Editorial team

Loss of the sense of smell is a major symptom of chronic rhinosinusitis with nasal polyps, affecting up to 90% of patients.1,2 Smell loss, which results in considerable lifestyle and psychological disease burden3, is a key indicator of type 2 inflammation4 and may be the first sign of the disease recurrence.1,2

Type 2 Inflammation and Loss of Smell
  • Loss of the sense of smell is one of the major symptoms of CRSwNP1,2
  • It impacts patients QoL3, and may persist even after the surgery4
  • Type 2 inflammation may play a role in yielding anosmia/hyposmia5
  • It affects ≈90% of CRSwNP patients1
  • Anosmia/hyposmia can be an early indicator of disease recurrence1,2
  • Degree of type 2 inflammation is correlated with severity of impairment of smell1,2

Smell loss is associated with type 2 inflammation5–9
Smell loss is associated with type 2 inflammation

 

Smell loss represents a major burden for CRSwNP patients1,2
Reduced quality of life (HR-QoL)
Reduced quality of life (HR-QoL)1,10
Daily activities are affected
Daily activities are affected3
Depression, anxiety, phobia, irritation, fatigue etc.
Depression, anxiety, phobia, irritation, fatigue etc.3
Altered interpersonal relationships
Altered interpersonal relationships11
Economic burden, decreased productivity
Economic burden, decreased productivity12

 

Smell improvement as measure of disease control

1 - International Guidelines

Emphasize the importance of the loss of the ability to smell as a treatment target13-14

2 - Assessment of olfaction15-18

Is crucial for clinical evaluation of CRS1

3 - Management of smell loss

Is complex and requires a multifaceted approach19-21

Abbreviations

CRS, chronic rhinosinusitis; CRSwNP, chronic rhinosinusitis with nasal polyps; HR-QoL, health-related quality of life; QoL, quality of life.

  1. Yan X, et al. Laryngoscope Investig Otolaryngol. 2020;5(6):992-1002;

  2. Rouyar A, et al. Allergy. 2019;74(3):549-559;

  3. Mullol J, et al. J Allergy Clin Immunol Pract. 2022;10(6):1434-1453.e9;

  4. Seys SF, et al. Allergy. 2020;75(11):2867-2878;

  5. Dekeyser A, et al. Int J Mol Sci. 2024;25:4460;

  6. Bachert C, et al. Front Immunol. 2024;15:1356298;

  7. Lee K, et al. Int J Mol Sci. 2021;92:910;

  8. Fokkens WJ, et al. Rhinology. 2020;58:1-464;

  9. Stevens WW, et al. J Allergy Clin Immunol Pract. 2016;4:565-572;

  10. Hopkins C, et al. Otolaryngol Head Neck Surg. 2024;170(4):1173-1182;

  11. Patel ZM, et al. Int Forum Allergy Rhinol. 2022;12(4):327-680;

  12. Schlosser RJ, et al. Int Forum Allergy Rhinol. 2017;7(1):50-55;

  13. Fokkens WJ, et al. Rhinology. 2024;62(3):287-298;

  14. Orlandi RR, et al. Int Forum Allergy Rhinol. 2021;11(3):213-739;

  15. Rumeau C, et al. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133(3):203-206;

  16. Brumm MC, et al. Neurology. 2023;100(16):e1691-e1701;

  17. Mullol J, et al. J Allergy Clin Immunol Pract. 2022;10(4):1086-1095.e5;

  18. Doulaptsi M, et al. Clin Transl Allergy. 2018;8:32;

  19. Marglani O, et al. J Asthma Allergy. 2023;16:1055-1063;

  20. Senna G, et al. Multidiscip Respir Med. 2022;17(1):813;

  21. Buchheit KM and Holbrook EH. Chronic rhinosinusitis with nasal polyposis: Management and prognosis. UpToDate. 2023. Available at UpToDate. Last accessed on 28 Aug 2024.

Gerelateerde paginas

Cycle of Recurrence: A Challenge in CRSwNP Patients

Cycle of Recurrence: A Challenge in CRSwNP Patients

Leer meer
Chronic Rhinosinusitis with Nasal Polyps: More Than Just Nasal Obstruction

Chronic Rhinosinusitis with Nasal Polyps: More Than Just Nasal Obstruction

Leer meer
Loss of Smell in CRSwNP

Loss of Smell in CRSwNP

Loss of sense of smell is a common symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), but its impact is often underestimated. Learn how olfactory dysfunction affects patient’s quality of life and explore the underlying mechanisms driving smell loss in CRSwNP.

Leer meer
MAT-BE-2600575 (v1.0) 04/05/2026