Reflekter over ny tilgang til KOL

Forfatter : Sanofi

Editorial Team

At få en forståelse for type 2 inflammation^* kan belyse hvorfor nogle KOL-patienter fortsætter med at få eksacerbationer. Se denne video og lær mere.¹

Tænk hvis du kunne identificere høj-risiko patienter?

Ved at få identificeret type 2 inflammationen hos KOL-patienten, vil åbne op for nye muligheder. Kig på eosinofile celletal i blodet, en biomarkør til KOL med type 2 inflammation^*, som kan hjælpe dig identificere hvilke patienter som har en øget risiko for at få nye eksacerbationer.¹

Se videoen nedenfor for bedre at forstå forværringer af KOL og bedre identificere risikopatienter.¹

Ignite new thinking in COPD - COPD, chronic obstructive pulmonary disease

In patients with COPD, exacerbations may :

Increase the risk of another¹
Accelerate lung function decline²
Increase morbidity and mortality risk^1,3-6

Different types of chronic inflammation have an important role in COPD^7-15
Type 2 inflammation and beyond type 2 inflammation
Identifying COPD patients with type 2 inflammation may help determine those at increased risk of exacerbations¹⁶
Look for blood eosinophils, a biomarker of COPD with type 2 inflammation^17,18,a,b
EOS ≥ 300 cells/ μL à 32% increased risk of COPD exacerbations^16a,b
Understanding type 2 inflammation in COPD may shed light on why some patients continue to experience exacerbations

^a Results from an observational analysis of 1553 patients with GOLD spirometry grade 2-4 COPD evaluating the relationship between blood eosinophil count and COPD exacerbation risk.
^bStratified analysis confirmed that increased exacerbation risk was driven by subjects with a history of frequent exacerbations, defined as ≥2 exacerbations per year.

Suissa S, Dell’Anello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67(11):957-963.
Halpin DMG, Decramer M, Celli BR, Mueller A, Metzdorf N, Tashkin DP. Effect of a single exacerbation on decline in lung function in COPD. Respir Med. 2017;128:85-91.
Hartl S, Lopez-Campos JL, Pozo-Rodriguez F, et al. Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit. Eur Respir J. 2016;47(1):113-121.
Jones SE, Barker RE, Nolan CM, Patel S, Maddocks M, Man WDC. Pulmonary rehabilitation in patients with an acute exacerbation of chronic obstructive pulmonary disease. J Thorac Dis. 2018;10(suppl 12):S1390-S1399.
Goërtz YMJ, Spruit MA, Van’t Hul AJ, et al. Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation. Ther Adv Respir Dis. 2019;13:1753466619878128. doi:10.1177/1753466619878128
Miravitlles M, Worth H, Soler Cataluña JJ, et al. Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study. Respir Res. 2014;15(1):122. doi:10.1186/s12931-014-0122-1
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Tajti G, Gesztelyi R, Pak K, et al. Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation. Int J Chron Obstruct Pulmon Dis. 2017;12:873-884.
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Aghapour M, Raee P, Moghaddam SJ, Hiemstra PS, Heijink IH. Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure. Am J Respir Cell Mol Biol. 2018;58(2):157-169.
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Barberá JA, Peinado VI, Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J. 2003;21(5):892-905.
Yun JH, Lamb A, Chase R, et al; for the COPDGene and ECLIPSE Investigators. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018;141(6):2037-2047.e10.
Halpin DMG, Dransfield MT, Han MK, et al. The effect of exacerbation history on outcomes in the IMPACT trial. Eur Respir J. 2020;55:1901921. doi:10.1183/13993003.01921-2019
Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2023 report). Accessed [June 2, 2023]. https://goldcopd.org/2023-gold-report-2/

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^* Type 2 inflammation hos KOL er defineret ved forhøjet biomarkør. (Eosinofile celler i blodet >300 µL eller >2% eller eosinofile celler i sputum på > 3%)

Referencer

Yun JH, Lamb A, Chase R, et al; for the COPDGene and ECLIPSE Investigators. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018;141(6):2037-2047.e10.