Global Developments in Early Detection
of Autoimmune Type 1 Diabetes
Curious about the characteristics of pre-symptomatic- and stage 3 Type 1 Diabetes? Interested in learning about the potential benefits of screening for autoimmune Type 1 Diabetes?
This short film gives you an overview of recent developments in diagnosis of Type 1 Diabetes, showcasing how early detection efforts can benefit those who need it the most.
Type 1 Diabetes (T1D) is an autoimmune condition which occurs when the immune system accidentally attacks the insulin-producing beta cells in the pancreas.1 The immune system’s attack leads to a progressive decline in beta cell function and leads the body to produce less insulin.2,3
Autoimmune T1D progresses in 3 stages where the first two stages are pre-symptomatic.3-6
The autoimmunity and the progressive decline in functional beta cell mass often begin months to years before the onset of more commonly known symptoms of Type 1 Diabetes.3-6
Autoimmune T1D may present with preventable life-threatening complications, such as diabetic ketoacidosis, which can lead to hospitalization and leave a severe psychological impact.7-11
Early detection of autoimmune T1D may positively affect longevity and decreases morbidity.
Early detection may also have a significant impact on the quality of life and mental health of those who are diagnosed and their families.12-17
Proactive testing for diabetes-specific autoantibodies can transform lives by detecting autoimmune T1D before symptoms develop.18-19
This animation was developed in collaboration with European Diabetes Forum (EUDF), International Diabetes Federation Europe, Federación Española de Diabetes (FEDE), Parliamentarians for Diabetes Global Network and Sanofi.
Referencer
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Diabetes.co.uk: https://www.diabetes.co.uk/body/beta-cells.html (Accessed October 2024)
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Powers AC (2021) J Clin Invest. 131(8)e142242
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Insel RA et al. (2015) Diabetes Care. 38(10) 1964-1974
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DiMeglio LA, et al. (2018) Lancet. 391(10138) - 2449-2462
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Marré ML et al. (2015) Front Cell Dev Biol. 3 67
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Phillip et al. (2024) Diabetes Care, 1, 47(8),pp.1276-1298
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Nakhla M et al. (2018) CMAJ. 190(14)E416-E421
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Cameron FJ et al. (2014). Diabetes Care. 37(6) 1554-1562
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Smith LB, et al. Pediatr Diabetes. 2018 19(5) 1025-1033
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Kimbell et al. (2021) BMC Pediatrics vol. 21, Article no. 160
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Rikos N, et al. (2022) NursRep. 12(3)564-573
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Schneider J et al. (2023) Diabetologia. 66(12) pp.2387-2388
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Hummel et al. (2023) Diabetologia, Vol. 66, pp. 1633–1642
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David MN et al. (2014) Diabetes Care 37(1), pp 9–16
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Jeyam A et al. (2021) Diabetes Care 44, pp390–398
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Rankin D et al. (2014) Pediatric Diabetes, vol. 15, issue 8, pp543-610
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Nieuwesteeg A et al. (2016) Diabetic Medicine June 2017, vol. 34, issue 6, pp741-867
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Narendran P. (2018) Diabetologia. 62(1) 24-27
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Raab J et al. (2016) BMJ Open 6-e011144