Studier på: kronisk rhinosinuitis med næsepolypper (CRSwNP)
Registreringsstudie på CRSwNP og Dupixent
SINUS24/52
Registreringsstudie fra LIBERTY
SINUS24/52: Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trial.
Bachert C et al. Lancet, 2019 Nov 2;394(10209):1638-1650. doi: 10.1016/S0140-6736(19)31881-1. Epub 2019 Sep 19.
Dupilumab improved objective and patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and complete nasal obstruction
Martin Wagenmann, Claus Bachert, Claire Hopkins, Mark Corbett, Jérôme Msihid, Scott Nash, Yamo Deniz, Paul J. Rowe, Harry Sacks, Juby A. Jacob-Nara
Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials.
Mullol J et al. Allergy. 2021;00:1–14. DOI: 10.1111/all.15067
Dupilumab efficacy in patients with chronic rhinosinusitis with nasal polyps with and without allergic rhinitis
Peters AT, Wagenmann M, Bernstein JA, Khan AH, Nash S, Jacob-Nara JA, Siddiqui S, Rowe PJ, Deniz Y. Dupilumab efficacy in patients with chronic rhinosinusitis with nasal polyps with and without allergic rhinitis. Allergy Asthma Proc. 2023 Jul 1;44(4):265-274. doi:10.2500/aap.2023.44.230015.
Prevalence of type 2 inflammatory signatures and efficacy of dupilumab in patients with chronic rhinosinusitis with nasal polyps from two phase 3 clinical trials: SINUS-24 and SINUS-52
Claus Bachert MD, PhD, Asif H. Khan MBBS, PhD, MPH, Stella E. Lee MD, Claire Hopkins DM, Anju T. Peters MD, Wytske Fokkens MD, PhD, Amy Praestgaard MSc, Amr Radwan MB, BChir, Scott Nash MD, Juby A. Jacob-Nara MD, Yamo Deniz MD, Paul J. Rowe MD
Int Forum Allergy Rhinol. 2023;1–11. DOI: 10.1002/alr.23249
Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real-life study (DUPIREAL)
Eugenio De Corso et al. 2023 https://doi.org/10.1111/all.15772
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis
Paul Oykhman, MD, MSc, et al. https://doi.org/10.1016/j.jaci.2021.09.009
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