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Global Developments in Early Detection
of Autoimmune Type 1 Diabetes

Author : Sanofi Editorial Team
Reading Time: 5 min

Curious about the characteristics of pre-symptomatic- and stage 3 Type 1 Diabetes? Interested in learning about the potential benefits of screening for autoimmune Type 1 Diabetes?

This short film gives you an overview of recent developments in diagnosis of Type 1 Diabetes, showcasing how early detection efforts can benefit those who need it the most.

Type 1 Diabetes (T1D) is an autoimmune condition which occurs when the immune system accidentally attacks the insulin-producing beta cells in the pancreas.1 The immune system’s attack leads to a progressive decline in beta cell function and leads the body to produce less insulin.2,3

Autoimmune T1D progresses in 3 stages where the first two stages are pre-symptomatic.3-6

The autoimmunity and the progressive decline in functional beta cell mass often begin months to years before the onset of more commonly known symptoms of Type 1 Diabetes.3-6

Autoimmune T1D may present with preventable life-threatening complications, such as diabetic ketoacidosis, which can lead to hospitalization and leave a severe psychological impact.7-11

Early detection of autoimmune T1D may positively affect longevity and decreases morbidity.

Early detection may also have a significant impact on the quality of life and mental health of those who are diagnosed and their families.12-17

Proactive testing for diabetes-specific autoantibodies can transform lives by detecting autoimmune T1D before symptoms develop.18-19

This animation was developed in collaboration with European Diabetes Forum (EUDF), International Diabetes Federation Europe, Federación Española de Diabetes (FEDE), Parliamentarians for Diabetes Global Network and Sanofi.

  1. Diabetes.co.uk: https://www.diabetes.co.uk/body/beta-cells.html (Accessed October 2024)

  2. Powers AC (2021) J Clin Invest. 131(8)e142242

  3. Insel RA et al. (2015) Diabetes Care. 38(10) 1964-1974

  4. DiMeglio LA, et al. (2018) Lancet. 391(10138) - 2449-2462 

  5. Marré ML et al. (2015) Front Cell Dev Biol. 3 67

  6. Phillip et al. (2024) Diabetes Care, 1, 47(8),pp.1276-1298

  7. Nakhla M et al. (2018) CMAJ. 190(14)E416-E421

  8. Cameron FJ et al. (2014). Diabetes Care. 37(6) 1554-1562

  9. Smith LB, et al. Pediatr Diabetes. 2018 19(5) 1025-1033

  10. Kimbell et al. (2021) BMC Pediatrics vol. 21, Article no. 160

  11. Rikos N, et al. (2022) NursRep. 12(3)564-573

  12. Schneider J et al. (2023) Diabetologia. 66(12) pp.2387-2388

  13. Hummel et al. (2023) Diabetologia, Vol. 66, pp. 1633–1642

  14. David MN et al. (2014) Diabetes Care 37(1), pp 9–16

  15. Jeyam A et al. (2021) Diabetes Care 44, pp390–398

  16. Rankin D et al. (2014) Pediatric Diabetes, vol. 15, issue 8, pp543-610 

  17. Nieuwesteeg A et al. (2016) Diabetic Medicine June 2017, vol. 34, issue 6, pp741-867

  18. Narendran P. (2018) Diabetologia. 62(1) 24-27

  19. Raab J et al. (2016) BMJ Open 6-e011144

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MAT-BE-2400990–v1.0–OCT/2024