Polypose naso-sinusienne (PNS)

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic, type 2 inflammatory disease that often remains uncontrolled despite standard medical and surgical treatment. According to the international EUFOREA definition, uncontrolled CRSwNP is defined by¹:

• 1. Patient-reported lack of control
• 2. Clinically relevant symptoms of active disease

Dupilumab's* efficacy and safety in severe CRSwNP was established in the LIBERTY NP SINUS-24 and SINUS-52 randomized, double-blind, placebo-controlled phase 3 trials, and is reflected in the approved SmPC.^1,2

As real-world context to this robust RCT evidence, the observational RELIBIO study** provides additional insight into clinical effectiveness, treatment response, and switching patterns among 360 patients with severe CRSwNP treated with dupilumab (n=53), omalizumab (n=65) and mepolizumab (n=242) in routine Belgian clinical practice.³

This Italian monocentric study (De Corso et al., 2022) evaluated the real-life effectiveness of dupilumab over the first year of treatment of severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) (N=57).² The results from this real-life observational study reinforces the efficacy of dupilumab demonstrated in the SINUS-24 and SINUS-52 randomized clinical trials and both the study design and results are consistent with the approved SmPC.^1,2,3

Loss of sense of smell is a common symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), but its impact is often underestimated. Learn how olfactory dysfunction affects patient’s quality of life and explore the underlying mechanisms driving smell loss in CRSwNP.

The results from the DUPIREAL real-world study reinforce the efficacy of dupilumab demonstrated in the SINUS-24 and SINUS-52 randomized clinical trials and are consistent with the approved SmPC.^1,2,3,4 DUPIREAL is the largest long-term real-world study (n=926) evaluating the effectiveness of dupilumab, including treatment response, disease control and remission, in severe uncontrolled CRSwNP over 2 years.^3,4

In this episode of Polyp Gossip, we explore the real-life journey of living with CRSwNP in this special episode dedicated to Global CRSwNP Awareness Day. Hear powerful stories from two patients in Denmark and Belgium, alongside expert insights from Sweden and a leading voice in patient advocacy from EUFOREA. Together, they shed light on challenges, breakthroughs, and the importance of raising awareness to improve care and outcomes.

In this episode of Polyp Gossip, two patients — Mr. Andrew Knill from the UK and Mrs. Chabha Djouder from France — share their personal journeys of living with CRSwNP and the profound impact of smell loss on their daily lives. Through their stories, they explore the emotional, social, and practical challenges of anosmia, while highlighting how access to care, diagnosis, and treatment pathways can differ from country to country. A powerful patient-led perspective on what “life without smell” really means.

Polyp Gossip is a video podcast dedicated to exploring Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Hosted by two globally recognized rhinologists. The show delves into trending topics, latest advancements, and patient experiences. Each episode features esteemed guests, including experts and patients, offering valuable insights into the evolving world of CRSwNP.

In this episode of Polyp Gossip, we uncover the truth about steroids in CRSwNP—exploring their benefits, limitations, and impact on long-term management. Our experts cut through the myths to reveal what every patient and clinician should really know.

In this episode of Polyp Gossip, we delve into the everyday impact of CRSwNP, examining how breathing difficulties, loss of smell, and emotional well-being are deeply interconnected. Join leading experts and patients as they share insights and experiences on living with this condition. Their perspectives shed light on the human side of CRSwNP, reminding us that every symptom affects far more than health.

Can remission become the new benchmark in CRSwNP care? In this episode, our expert panel explores the evolving treatment landscape and what "remission" truly means for patients and clinicians. Join us as we look ahead to a future beyond symptom control - where long-term outcomes and deeper disease understanding could transform the way we define treatment success.

What links CRSwNP, asthma, and other comorbidities? In this episode, our experts unpack the unified airways concept and why it’s key to understanding Type 2 inflammation and optimizing patient care. Our experts discuss integrated care approaches and what they mean for clinical practice.