Thrombose

Felicita Andreotti, Italy; Christiaan J M Vrints, Belgium

PRALUENT^®: a powerful PCSK9i that ticks all the boxes^1–4

PRALUENT is a PCSK9i that reduces the levels of LDL-C in the blood.² It is a fully human IgG1 monoclonal antibody that works by inhibiting the binding of PCSK9 to LDL- receptors. As a result, PRALUENT increases the number of LDL-receptors available to clear LDL, thereby lowering LDL-C levels.² Elevated LDL-C levels have been significantly associated with cardiovascular disease such as heart attacks and strokes.¹

Key principles of lipid management (LDL-C in particular) in accordance with the 2019 ESC/EAS Guidelines for the management of dyslipidaemias, and the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes.

The usual starting dose for PRALUENT is 75 mg administered subcutaneously once every 2 weeks. Patients requiring larger LDL-C reduction (>60%) may be started on 150 mg once every 2 weeks, or 300 mg once every 4 weeks (monthly), administered subcutaneously.²

Despite major advances in our understanding of atherosclerosis, ASCVD remains the leading cause of death globally.¹

Roth Eli M et al. Atherosclerosis vol. 254 (2016): 254-262

Prof. Dr. Halvorsen, Prof. Dr. Sinnaeve & Prof. Dr. Martens