Expert video: Complex type 2 inflammation, refreshingly simple
Professor Lipworth provides quick insight with the bucket model.
Several cytokines play a role in type 2 inflammation, and the number of biologics that can inhibit those cytokines is growing. Which cytokines play which role? And which biologically inhibits which cytokine? This expert video makes it clear in 4 minutes.
The bucket model is a schematic representation of type 2 inflammation, in which the role of the alarmins (TSLP and IL-33), effector cytokines (IL-5, IL-4, IL-13) and the associated biomarkers is easily demonstrated. Professor Lipworth thus makes the complex immunology understandable and provides practical tools. This knowledge may provide support in choosing the appropriate biological for your severe type-2 asthma patient.
Watch the bucket explainer
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Professor Brian Lipworth is the head of the Scottish Centre for Respiratory Research at the University of Dundee. His research group was founded in 1991 and has an international reputation in the field of clinical research into the respiratory tract. The combination of his leading expertise in research and in the clinic provides unique insights into the treatment of asthma and COPD and the role of biologics in this.1 |
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B.J. Lipworth, R. Greig, R. Chan, C. R. Kuo, and C. Jackson, "Head-To-Head Comparison of Biologic Efficacy in Asthma: What Have we Learned?," Allergy 80, no. 5 (2025):1226-1241.
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