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When to suspect TTP?

TTP is rare and presents similarly to other thrombotic microangiopathies (TMAs), making it difficult to diagnose.

aTTP is a medical emergency: diagnosing aTTP rapidly is critical and can save a life1

When a patient presents with:1

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Severe thrombocytopenia
(often platelets <30 × 109/L)

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Microangiopathic hemolytic anemia (MAHA)
characterized by the presence of schistocytes in blood smear

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With no identified cause

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Why TTP can be difficult to diagnose?

TTP is rare and presents similarly to other thrombotic microangiopathies (TMAs), making it a challenge to diagnose. All TMAs result in thrombosis of capillaries and arterioles due to endothelial injury.2,3

Suspect aTTP_how to diagnose

Tests and expected results in patients with suspected aTTP1

diagnostics

Diagnosis of TTP

Dr Marie Scully shares details on how to make a prompt differential diagnosis of TTP.

Referenties

MAT-BE-2401121 - 1.0 - 12/2024